How is naloxone used in opioid overdose and what route and dosing considerations maximize safety?

• A. Opioid receptor antagonist to reverse respiratory depression; IV, IM, or intranasal; start with 0.4–2 mg IV and titrate every 2–3 minutes until respiration improves
• B. Naloxone should be given intranasally only at a fixed 4 mg dose
• C. Naloxone is given orally in a single 10 mg dose
• D. Naloxone has no role in reversing opioid overdose

Answer: (D)