How should you assess and mitigate opioid-related respiratory depression risk in opioid-naïve patients?

• A. Start with a high, long-acting dose
• B. Start with a low, short-acting dose and titrate gradually; monitor respiratory rate and mental status; avoid concurrent CNS depressants; educate patient/caregivers
• C. Use only very high doses to ensure rapid relief
• D. Routinely administer sedatives to prevent agitation

Answer: (B)