What is a PAMORA and when is it used?

• A. PAMORAs (e.g., naloxegol, methylnaltrexone) block peripheral mu receptors to treat opioid-induced constipation without reversing central analgesia; used when laxatives fail
• B. They are central opioid receptor agonists used for acute pain
• C. They prevent opioid tolerance from developing
• D. They replace opioids for analgesia

Answer: (A)