What is the maximum recommended daily dose of acetaminophen in adults and what factors modify this limit?

• A. 2,000 mg/day; unchanged by liver disease.
• B. Generally 4,000 mg/day; lower in chronic liver disease, significant alcohol use, or when taking hepatotoxic drugs; adjust in elderly or hepatic impairment.
• C. 6,000 mg/day; adjusted for age only.
• D. 8,000 mg/day; no adjustments for hepatic status.

Answer: (B)