What is the mechanism of action of capsaicin topical therapy and when should patients expect to see benefits?

• A. Capsaicin depletes substance P and causes defunctionalization of nociceptors; consistent use over weeks is typically required to perceive meaningful benefit
• B. Capsaicin inhibits COX enzymes
• C. Capsaicin increases endorphin release
• D. Capsaicin increases peripheral blood flow

Answer: (A)