What is the per-dose range for ibuprofen in children?

• A. 15–20 mg/kg
• B. 5–10 mg/kg
• C. 2–4 mg/kg
• D. 10–15 mg/kg

Answer: (B)

Weight-based dosing for ibuprofen in children uses a per-dose range of 5–10 mg/kg. This range provides reliable fever and pain relief while minimizing the risk of NSAID-related side effects. Doses much lower than this (like 2–4 mg/kg) would be subtherapeutic, not reliably reducing symptoms. Doses higher than this per administration (such as 15–20 mg/kg) increase the chance of adverse effects on the stomach and kidneys and may raise the risk of overdose when repeated. In practice, give 5–10 mg/kg every 6–8 hours as needed, with a maximum of about 40 mg/kg per day. For comparison, acetaminophen dosing is typically 10–15 mg/kg per dose, highlighting why the ibuprofen per-dose range is distinct.