Which CNS depressants commonly interact with opioids to increase respiratory depression risk, and what is the recommended approach?

• A. Benzodiazepines, alcohol, and other sedatives; limit concurrent use, choose non-sedating alternatives when possible, and closely monitor if combination is unavoidable.
• B. Antihistamines; avoid entirely.
• C. Stimulants; co-prescribe to offset sedation.
• D. Acetaminophen; no changes.

Answer: (A)