When would you consider using a COX-2 selective inhibitor, and what is a key cardiovascular risk associated with this class?

• A. In patients at high GI risk who do not have significant CV risk; key cardiovascular risk is increased risk of myocardial infarction and stroke vs nonselective NSAIDs.
• B. In patients with significant cardiovascular risk; GI risk is negligible.
• C. In patients with both high GI and high CV risk.
• D. Avoid in all patients.

Answer: (A)